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Histone-binding protein RBBP4?(also known as?RbAp48, or?NURF55) is a?protein?that in humans is encoded by the?RBBP4?gene. This gene encodes a ubiquitously expressed nuclear protein that belongs to a highly conserved subfamily of?WD-repeat?proteins. It is present in protein complexes involved in?histone acetylation?and?chromatin?assembly. It is part of the?Mi-2/NuRD complex?complex that has been implicated in?chromatin remodeling?and transcriptional repression associated with histone deacetylation. This encoded protein is also part of?corepressor?complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to?retinoblastoma protein?to regulate cell proliferation. A decrease of RbAp48 in the?dentate gyrus?(DG) of the?hippocampus?in the?brain?is suspected to be a main cause of?memory loss?in normal?aging?(PMID: 23986399).